Methanol → Methyl 5-bromo-2,4-dihydroxybenzoate

HRID 1643333Notes

Reaction equation

HRID 1643333 reaction equation
[Br:1][C:2]1[C:3]([OH:12])=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].S(=O)(=O)(O)O.[CH3:18]O>>[Br:1][C:2]1[C:3]([OH:12])=[CH:4][C:5]([OH:11])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:18])=[O:8]

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 818145-Bromo-2,4-dihydroxybenzoic acid

Product 1

HCID 44828918Methyl 5-bromo-2,4-dihydroxybenzoate

Procedure

1.1 80 g of 5-bromo-2,4-dihydroxybenzoic acid are initially introduced in 1 l of methanol, 8 ml of sulfuric acid are added, and the mixture is boiled for 16 hours. The solvent is removed, the residue is taken up in MTB ether, and the solution is subjected to conventional work-up, giving 80 g of methyl 5-bromo-2,4-dihydroxybenzoate.

Workup

  1. customThe solvent is removed

Sources & evidence

ORD record
ord-ec87ecaf673844e78466798a9082236f
Source dataset
uspto-grants-2012_02
Patent number
US08119795B2

Reaction notes

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