HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → Methyl 5-bromo-2,4-dibenzyloxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Methyl 5-bromo-2,4-dihydroxybenzoate | HCID 44828918 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Methyl 5-bromo-2,4-dibenzyloxybenzoate | HCID 59317108 | — |
Reaction Steps
1.2 92.6 g of potassium carbonate are added to a solution of 80 g of methyl 5-bromo-2,4-dihydroxybenzoate in 1 l of acetonitrile, and 77 ml of benzyl bromide are added dropwise. The mixture is heated for 3 hours and cooled, the solvent is removed, and the residue is subjected to conventional work-up, giving 150 g of methyl 5-bromo-2,4-dibenzyloxybenzoate (crude product).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119795B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-cb305b13ae1d4f2c9d38c81c8475bdd5 |
| Source note | uspto-grants-2012_02 |