HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[(1,1-Dimethylethoxy)carbonyl]-3-[(2-nitrophenyl)amino]-L-alanine → (2S)2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[(1,1-Dimethylethoxy)carbonyl]-3-[(2-nitrophenyl)amino]-L-alanine | HCID 22881947 | — |
| Reactant | (3S)-2-Oxo-3-tert-butoxycarbonylamino-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine-1-acetic acid methyl ester | HCID 54305289 | — |
| Reactant | 3-Chloro-3-nitro pyridine | HCID 66756668 | — |
| Product | (2S)2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid | HCID 18396553 | — |
Reaction Steps
(2S)2-tert-Butoxycarbonylamino-3-(3-nitropyridin-2-ylamino)propionic acid was prepared by a similar method as (2S)2-tert-butoxycarbonylamino-3-(2-nitrophenyl-amino)propionic acid in Step A of the synthesis of 600a/103, except that 3-chloro-3-nitro pyridine was used instead of 2-fluoronitrobenzene, to give 4.05 g (64%) of a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119631B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-9493368df32f41dabc0fe1fe45fa6753 |
| Source note | uspto-grants-2012_02 |