8-Quinolinecarboxaldehyde → (8-methylquinolin-7-yl)(1-trityl-1H-imidazol-4-yl)methanone

HRID 1643397Notes

Reaction equation

HRID 1643397 reaction equation
CON(C)[C:4]([C:6]1[C:15]([CH3:16])=[C:14]2[C:9]([CH:10]=[CH:11][CH:12]=[N:13]2)=[CH:8][CH:7]=1)=[O:5].I[C:19]1[N:20]=[CH:21][N:22]([C:24]([C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[CH:23]=1.CC1N=CN(C(C2C=CC=CC=2)(C2C=CC=CC=2)C2C=CC=CC=2)C=1C(C1C=CC=C2C=1N=CC=C2)O.N1C2C(=CC=CC=2C=O)C=CC=1>>[CH3:16][C:15]1[C:6]([C:4]([C:19]2[N:20]=[CH:21][N:22]([C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:23]=2)=[O:5])=[CH:7][CH:8]=[C:9]2[C:14]=1[N:13]=[CH:12][CH:11]=[CH:10]2

Participants

5

Reactant 4

HCID 1701038-QuinolinecarboxaldehydeHCID 6182524-Iodo-1-tritylimidazoleHCID 59749553N-Methoxy-N,8-dimethylquinoline-7-carboxamideHCID 66755693HCID 66755693, compound

Product 1

HCID 59749533(8-methylquinolin-7-yl)(1-trityl-1H-imidazol-4-yl)methanone

Procedure

(8-Methylquinolin-7-yl)(1-trityl-1H-imidazol-4-yl)methanone (21) was synthesized from (20) and 4-iodo-1-trityl-1H-imidazole via the procedure used in the preparation of (4) from (3) above.

Sources & evidence

ORD record
ord-5bf0a6be995d44e19c3300cf564637d5
Source dataset
uspto-grants-2012_02
Patent number
US08119807B2

Reaction notes

Loading…