反应详情

To a solution of tert-butyl 4-(nitrooxy)piperidine-1-carboxylate (2.10 g; 8.53 mmol) in DCM (15 mL) cooled to 0° C., HCl gas was bubbled for 2 hrs. The solvent was concentrated and the residue was treated with diethyl ether, affording the title compound which was used in subsequent steps without further purification.

1. customHCl gas was bubbled for 2 hrs
2. concentrationThe solvent was concentrated
3. additionthe residue was treated with diethyl ether