反应详情

To a stirred solution of compound obtained in Step B (3.59 g, 14.24 mmol) and TEA (1.98 ml, 14.24 mmol) in DCM (50 ml), 4-Nitrobenzoyl chloride (2.64 g, 14.24 mmol) was added and the reaction was stirred overnight at r.t. The organic phase was washed with a solution of NaH2PO4 5% and brine, dried (MgSO4) and evaporated under reduced pressure. The crude was crystallized from EtOAc at 0° C. adding n-hexane. The product was obtained as a pale yellow solid.

1. washThe organic phase was washed with a solution of NaH2PO4 5% and brine
2. dry with materialdried (MgSO4)
3. customevaporated under reduced pressure
4. customThe crude was crystallized from EtOAc at 0° C.
5. additionadding n-hexane
6. customThe product was obtained as a pale yellow solid