Piperazine → 1-(Thiazol-2-yl)piperazine

Participants

Reaction Steps

2-Bromothiazole (15 g, 91.45 mmol) and piperazine (27.6 g, 320 mmol) were dissolved in 1-butanol (290 ml) and the solution was refluxed for 5 h and stirred at room temperature for 15 h. The precipitate was filtered off, the mother liquor was concentrated and saturated sodium carbonate solution (100 ml) was added to the residue. The mixture was extracted with methylene chloride (2×80 ml) and the organic phases were combined, dried over magnesium sulfate and concentrated in vacuo. The crude product was purified by column chromatography (silica gel) with ethyl acetate/methanol (1:1). Yield: 14.2 g (91%)

Provenance & Evidence