Hydrochloric Acid → HCID 66701289, compound

Participants

Reaction Conditions

Reaction Steps

tert-Butyl 7-(pyridin-4-yl)-2,7-diazaspiro[4.4]nonane-2-carboxylate (2.208 mmol, 1 eq) was heated at the boiling temperature with hydrogen chloride in methanol (1.25 M, 6 eq) for 30 min. The methanol was concentrated in vacuo, the residue was dissolved in analytical grade ethanol (5 ml), and analytical grade acetone (25 ml) was added. The mixture was stirred at 0° C. for 30 min and a pale precipitate precipitated out. This was filtered out, washed with diethyl ether and dried under a high vacuum to obtain the desired product. Yield: 0.55 g (90%)

Provenance & Evidence