4-(4-Cyano-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amide → HCID 178481872, compound

HRID 1643641Notes

Reaction equation

HRID 1643641 reaction equation
[CH3:1][N:2]1C=[CH:5][C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[C:24]([F:32])[CH:23]=3)[C:13]3[CH2:14][C:15]([CH3:18])([CH3:17])[O:16][C:12]=3[CH:11]=2)=[O:9])=[N:3]1.C[N:34]1N=C(NC(C2C=C(OC3C=CC(C#N)=C(F)C=3)C3CC(C)(C)OC=3C=2)=O)C=N1>>[CH3:1][N:2]1[N:3]=[C:4]([NH:7][C:8]([C:10]2[CH:20]=[C:19]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:31])[NH:29][OH:30])=[C:24]([F:32])[CH:23]=3)[C:13]3[CH2:14][C:15]([CH3:17])([CH3:18])[O:16][C:12]=3[CH:11]=2)=[O:9])[CH:5]=[N:34]1

Participants

3

Reactant 2

HCID 667555474-(4-Cyano-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amideHCID 178480465HCID 178480465, compound

Product 1

HCID 178481872HCID 178481872, compound

Procedure

The title compound was prepared in a similar manner as described for Intermediate 185a, from 4-(4-cyano-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid (2-methyl-2H-[1,2,3]triazol-4-yl)-amide (184) (150 mg, 0.368 mmol) and used without further purification for the next step.

Workup

  1. customused without further purification for the next step

Sources & evidence

ORD record
ord-334e198c5ca7481ca6642e8872e64bdc
Source dataset
uspto-grants-2012_02
Patent number
US08119624B2

Reaction notes

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