Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 16438생성일: 2026년 10월 25일
Sodium Carbonate → N-(2-Amino-6-phenyl-4-pyrimidinyl)-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine
https://huagongshe.com/reaction/16438
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | Phenylboronic Acid | HCID 66827 | — |
| 반응물 | N-[2-Amino-6-chloro-4-pyrimidinyl]-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine | HCID 17979350 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | Toluene ethanol | HCID 21863594 | — |
| 생성물 | N-(2-Amino-6-phenyl-4-pyrimidinyl)-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine | HCID 17979334 | — |
반응 단계
50 mg (130 μmol) of N-[2-amino-6-chloro-4-pyrimidinyl]-N-[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amine (from example 8) are suspended in 3 ml of toluene/ethanol (2:1), and 4.68 mg of tetrakis(triphenylphosphine)palladium(0) are added. After addition of 19.7 mg (160 μmol) of phenylboronic acid and 0.50 ml of 2M aqueous sodium carbonate solution, the mixture is stirred at 100° C. overnight. The mixture is evaporated to dryness using a rotary evaporator and purified by preparative HPLC.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US07737153B2 |
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| 출처 데이터셋 | uspto-grants-2010_06 |
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| ORD ID | ord-6e17ee2d1ec944e4b2706873a06f98cc |
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| 출처 메모 | uspto-grants-2010_06 |
|---|
