3-Chlorobenzaldehyde → HCID 59778146, compound

HRID 1643887Notes

Reaction equation

[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH2:6][CH:7]([NH:12][S:13]([C:16]3[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=3)(=[O:15])=[O:14])[CH2:8][NH:9]2)=[CH:4][CH:3]=1.Cl[C:25]1[CH:26]=[C:27]([CH:30]=[CH:31][CH:32]=1)[CH:28]=O>>[CH2:28]([N:9]1[C:10]2[C:5](=[CH:4][CH:3]=[C:2]([Cl:1])[CH:11]=2)[CH2:6][CH:7]([NH:12][S:13]([C:16]2[CH:21]=[C:20]([F:22])[CH:19]=[C:18]([F:23])[CH:17]=2)(=[O:15])=[O:14])[CH2:8]1)[C:27]1[CH:30]=[CH:31][CH:32]=[CH:25][CH:26]=1

Participants

Reactant 2

HCID 114773-Chlorobenzaldehyde

HCID 59778181HCID 59778181, compound

Product 1

HCID 59778146HCID 59778146, compound

Procedure

The title compound was prepared from 152C and 3-chlorobenzaldehyde by procedures analogous to those described in Example 22A. HPLC: 99% at 4.20 min (retention time) (Conditions: Phenom Prime S5, C18 (4.6×50 mm); Eluted with 0% to 100% B, 4 min gradient (A=90% H2O−10% MeOH−0.1% TFA and B=10% H2O−90% MeOH−0.1% TFA); Flow rate at 4.0 mL/min, UV detection at 220 nm). MS (ES): m/z 484 [M+H]+.

Workup

washEluted with 0% to 100% B, 4 min gradient (A=90% H2O−10% MeOH−0.1% TFA and B=10% H2O−90% MeOH−0.1% TFA)

Sources & evidence

ORD record: ord-318bf455897c48b5b1657a23a4bba49c
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119808B2

Reaction notes

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