Potassium Carbonate → HCID 66754935, compound

Participants

Reaction Steps

2.99 mg (1.56 mmol) of EDCl were added to a solution of 430 mg (1.42 mmol) of (6-chloro-2-oxo-2,3-dihydrobenzimidazol-1-yl)phenylacetic acid (VIIIa), 289 mg (2.13 mmol) of HOBt, 459 mg (0.1.70 mmol) of 1-pyridin-4-ylpiperazine and 1.24 ml (7.10 mmol) of ethyldiisopropylamine in dichloromethane (25 ml) while stirring in an ice-water bath. The reaction solution was slowly warmed and stirred at room temperature for 16 h. Half-saturated aqueous potassium carbonate solution was added, and the organic phase was separated off. The aqueous phase was extracted with ethyl acetate (4×50 ml), and the combined organic phases were washed with sat. NaHCO3 solution, dried over magnesium sulfate and concentrated under reduced pressure. The reaction product was used without further purification for the next reaction step. Yield: 439 mg (56%) of white solid

Provenance & Evidence