HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 16440Generated: October 25, 2026
Hydrochloric Acid → N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine
https://huagongshe.com/reaction/16440
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 2-Fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline | HCID 17979351 | — |
| Reactant | 4-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine | HCID 22324286 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[2-Amino-6-(4-pyridinyl)-4-pyrimidinyl]-N-[2-fluoro-4-(1H-pyrrolo[2,3-b]-pyridin-4-yloxy)phenyl]amine | HCID 17979301 | — |
Reaction Steps
11 mg (50 μmol) of 2-fluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline (from example XX) are suspended in 5 ml of water. 9.3 mg (50 μmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX) and 0.01 ml of concentrated hydrochloric acid are added, and the mixture is stirred at 100° C. overnight. For work-up, the reaction solution is made alkaline with saturated sodium bicarbonate solution and extracted 3× with ethyl acetate, and the extracts are dried over sodium sulfate and concentrated using a rotary evaporator.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07737153B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-1a4f22055d7242a888e06591430201e8 |
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| Source note | uspto-grants-2010_06 |
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