Sodium Hydroxide → Sodium 6-methoxynicotinate

HRID 1644084Notes

Reaction equation

HRID 1644084 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O:9]C)=[O:8])=[CH:5][N:4]=1.[OH-].[Na+:14]>O1CCOCC1>[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:6]([C:7]([O-:9])=[O:8])=[CH:5][N:4]=1.[Na+:14]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 586039Methyl 6-methoxypyridine-3-carboxylate

Product 1

HCID 23717611Sodium 6-methoxynicotinate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

methyl 6-methoxynicotinate (2.097 g, 12.56 mmol) was dissolved in dioxane (30 mL). An aqueous solution of NaOH (1.0N, 25 mL) was added to the solution and the mixture was stirred at room temperature overnight. The solvent was removed under reduced pressure to provide 2.2 g of sodium 6-methoxynicotinate.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-442c6916b3c24f61b9b5c99d6f167f1f
Source dataset
uspto-grants-2012_02
Patent number
US08124121B2

Reaction notes

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