L-Tyrosine → HCID 131729454, compound

Participants

Reaction Steps

With the exception of Z-Val-Tyr-OMe, Z-Val-Lys(Boc)-OMe and Z-Ala-Phe-D-Ala-OMe, all substrate peptides were quantitatively converted into products, i.e. the corresponding amide peptide and free carboxylic acid peptide, in 4 h reaction time. At longer reaction times also the methyl ester peptides ending with Tyr and Lys(Boc) were totally converted. Surprisingly, the methyl ester of the tripeptide with a C-terminal D-Ala residue was also converted. The HPLC analysis at 75 h reaction time showed conversion of 54 ala % of substrate to yield about 36 a/a % of the product Z-Ala-Phe-D-Ala-NH2.

Provenance & Evidence