反应详情

A mixture of 4a (1.5 g, 8.0 mmol) and trans cinnamic aldehyde (1.6 g, 12.0 mmol) in ethanol (20 ml) was heated under reflux for 3 h. After cooling to room temperature, the mixture was filtered, and the residue dried under vacuum (0.6 mbar) to give 0.51 g (21%) of a pale-yellow solid consisting of two isomers with respect to the amide bond conformation (E:Z ca. 3:1).

1. temperaturewas heated
2. temperatureunder reflux for 3 h
3. filtrationthe mixture was filtered
4. customthe residue dried under vacuum (0.6 mbar)