Hydrazinecarboxylic acid, ethyl ester → HCID 2164544, compound

HRID 1644170Notes

Reaction equation

HRID 1644170 reaction equation
[NH:1]([C:3]([O:5][CH2:6][CH3:7])=[O:4])[NH2:2].[CH:8]1[CH:13]=[CH:12][C:11](/[CH:14]=[CH:15]/[CH:16]=O)=[CH:10][CH:9]=1>C(O)C>[C:11]1(/[CH:14]=[CH:15]/[CH:16]=[N:2]/[NH:1][C:3]([O:5][CH2:6][CH3:7])=[O:4])[CH:12]=[CH:13][CH:8]=[CH:9][CH:10]=1

Participants

4

Reactant 2

HCID 20064Hydrazinecarboxylic acid, ethyl esterHCID 637511Cinnamaldehyde

Product 1

HCID 2164544HCID 2164544, compoundYield 80.8%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5a (4.00 g, 38.4 mmol) and trans cinnamic aldehyde (7.60 g, 57.5 mmol) in ethanol (100 ml) was heated under reflux for 3 h. After cooling to room temperature, the mixture was filtered, and the residue dried under vacuum to give 6.77 g of a white solid. Refiltration of the filtrate gave another 0.73 g of the residue and an overall yield of 91%.

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 3 h
  3. filtrationthe mixture was filtered
  4. customthe residue dried under vacuum

Sources & evidence

ORD record
ord-ed96b2d5facf47379f19aadb1fd3e654
Source dataset
uspto-grants-2012_02
Patent number
US08124578B2

Reaction notes

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