3,5,5-Trimethylhexanal → HCID 87146582, compound

Participants

Reaction Steps

A mixture of 12a (3.00 g, 19.0 mmol) and 3,5,5-trimethylhexanal (4.05 g, 28.4 mmol) in ethanol (48 ml) was heated under reflux for 2 h. After cooling to room temperature, the product was concentrated and washed with ethanol. Drying under high vacuum (0.33 mbar) gave a total of 4.69 g (88%) of a colorless oil consisting of two isomers with respect to the amide bond conformation (E:Z ca. 56:44).

Provenance & Evidence