HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-4-(6-nitropyridin-3-yl)piperazine → 5-(4-Methylpiperazin-1-yl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-4-(6-nitropyridin-3-yl)piperazine | HCID 51711484 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(4-Methylpiperazin-1-yl)pyridin-2-amine | HCID 22329833 | 98.2% |
Reaction Steps
Methyl-4-(6-nitro-pyridin-3-yl)-piperazine (1.748 g, 7.865 mmol) was stirred in 30 mL methanol with 175 mg 10% palladium on carbon under an atmosphere of hydrogen gas for 5 hours. This was filtered and concentrated in vacuo to yield 5-(4-Methyl-piperazin-1-yl)-pyridin-2-ylamine (1.485 g, 7.724 mmol). MS (ESI) 193.1 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124604B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-9a66b2a1c26b4ad687e7daee33bbfe01 |
| Source note | uspto-grants-2012_02 |