HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → (2E)-N-(2,3-difluorophenyl)-3-phenylacrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| Reactant | 2,3-Difluoroaniline | HCID 78278 | — |
| Reactant | (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide | HCID 874919 | — |
| Product | (2E)-N-(2,3-difluorophenyl)-3-phenylacrylamide | HCID 47450756 | — |
Reaction Steps
The compound was prepared from 2,3-difluoroaniline (5 g, 38.7 mmol) and cinnamoylchloride (6.45 g, 38.7 mmol) in the presence of 2,6-lutidine (6.8 mL, 58 mmol) as described for Intermediate 18 to give a colorless solid, 7.4 g (74%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124602B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-e54ea05366da420087321c933aa15d28 |
| Source note | uspto-grants-2012_02 |