HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one → 6-Acetyl-2H-1,4-benzoxazin-3(4H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-methoxy-3,4-dihydro-2H-1,4-benzoxazin-3-one | HCID 13204952 | — |
| Reactant | Ethyl (4-acetyl-2-nitrophenoxy)acetate | HCID 86642623 | — |
| Catalyst | Iron | HCID 23925 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 6-Acetyl-2H-1,4-benzoxazin-3(4H)-one | HCID 3641956 | 51% |
Reaction Steps
Ethyl(4-acetyl-2-nitrophenoxy)acetate (Intermediate 90) was reacted with iron in acetic acid as described for Intermediate 48. The crude product was obtained as an off white solid after work up. Recrystallization with ethyl acetate/methanol afforded the product as a colorless solid in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124602B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c056be5af8ee4101be58ebb686a0dde2 |
| Source note | uspto-grants-2012_02 |