1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → HCID 66775065, compound

HRID 1644377Notes

Reaction equation

HRID 1644377 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[O:19][CH2:18][C:17]2=[O:26])[CH2:10][CH2:9]1)(C)(C)C.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[O:19][CH2:18][C:17]2=[O:26])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642628HCID 86642628, compound2×

Product 1

HCID 66775065HCID 66775065, compound

Procedure

tert-Butyl{1-[2-(3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 98) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was obtained as a colorless solid and used without further purification for the next step (quantitative yield).

Sources & evidence

ORD record
ord-ef3190311d3b4475910c15f6da0af44f
Source dataset
uspto-grants-2012_02
Patent number
US08124602B2

Reaction notes

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