1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrile → HCID 66775170, compound

HRID 1644387Notes

Reaction equation

HRID 1644387 reaction equation
C(OC(=O)[NH:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:21]3[CH:22]=[C:23]([S:26]([CH2:29]C)(=[O:28])=[O:27])[CH:24]=[CH:25][C:20]=3[O:19][CH2:18][C:17]2=[O:31])[CH2:10][CH2:9]1)(C)(C)C.NC1CCN(CCN2C3C(=CC=C(C#N)C=3)C=CC2=O)CC1>>[NH2:7][CH:8]1[CH2:13][CH2:12][N:11]([CH2:14][CH2:15][N:16]2[C:21]3[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:20]=3[O:19][CH2:18][C:17]2=[O:31])[CH2:10][CH2:9]1

Participants

3

Reactant 2

HCID 602009201-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoline-7-carbonitrileHCID 86642630HCID 86642630, compound2×

Product 1

HCID 66775170HCID 66775170, compound

Procedure

tert-Butyl(1-{2-[6-(ethylsulfonyl)-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl]ethyl}piperidin-4-yl)carbamate (Intermediate 104) was reacted as described for Intermediate 14. The crude trifluoro acetate of the title compound was obtained as a colorless solid and used without further purification for the next step (quantitative yield).

Sources & evidence

ORD record
ord-63a4e4f8582e49948e0ed41092acba18
Source dataset
uspto-grants-2012_02
Patent number
US08124602B2

Reaction notes

Loading…