Ethyl oxoacetate → 6,7-Difluoro-1,2-dihydroquinoxalin-2-one

Beteiligte Stoffe

Reaktionsschritte

To a stirred solution of 4,5-difluorobenzene-1,2-diamine (4.7 g, 32.6 mmol) in ethanol (75 mL) was added ethyl oxoacetate (50 wt % in toluene, 13.3 mL, 65.3 mmol). The reaction was stirred at room temperature overnight. The resulting precipitate was collected by filtration, washed with ethanol, and dried under reduced pressure to give 4.3 g (73%) of the product as a colorless solid.

Herkunft & Nachweise