HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,4-Dioxane hydrochloride → 1-[2-(4-Aminopiperidin-1-yl)ethyl]quinolin-4(1H)-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | 1-[2-(4-Aminopiperidin-1-yl)ethyl]quinolin-2(1H)-one | HCID 66774921 | — |
| Reactant | tert-Butyl{1-[2-(4-oxoquinolin-1(4H)-yl)ethyl]piperidin-4-yl}carbamate | HCID 86642649 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-[2-(4-Aminopiperidin-1-yl)ethyl]quinolin-4(1H)-one | HCID 66774671 | 51.4% |
Reaction Steps
tert-Butyl{1-[2-(4-oxoquinolin-1(4H)-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 166, 480 mg crude, 1.29 mmol) was reacted with 4M HCl/dioxane in dioxane as described for Intermediate 163 to give 180 mg (51%) of the crude product as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124602B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-aac2a76e03ad410789c54f4dda6fdd3c |
| Source note | uspto-grants-2012_02 |