HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-Lutidine → (2E)-N-(3-Bromo-5-fluorophenyl)-3-phenylacrylamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-Lutidine | HCID 7937 | — |
| Reactant | 3-Phenylprop-2-enoyl chloride | HCID 66023 | — |
| Reactant | (2E)-N-(3-bromophenyl)-3-phenylprop-2-enamide | HCID 874919 | — |
| Reactant | 3-Bromo-5-fluoroaniline | HCID 15020155 | — |
| Product | (2E)-N-(3-Bromo-5-fluorophenyl)-3-phenylacrylamide | HCID 66774736 | 85% |
Reaction Steps
The compound was prepared from 3-bromo-5-fluoroaniline (Intermediate 180, 5.3 g, 27.9 mmol) and cinnamoylchloride (5.6 g, 33.5 mmol) in the presence of 2,6-lutidine (5.0 mL, 41.9 mmol) as described for Intermediate 18 to give the product as a colorless solid, 7.6 g (85% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124602B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-db86264766014705b172ff686b8ef29e |
| Source note | uspto-grants-2012_02 |