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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1644490Generated: October 26, 2026

Hydrochloric Acid → 1-[2-(4-Aminopiperidin-1-yl)ethyl]-6,8-difluoroquinoxalin-2(1H)-one

https://huagongshe.com/reaction/1644490

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant1-[2-(4-aminopiperidin-1-yl)ethyl]-5,7-difluoroquinoxalin-2(1H)-oneHCID 66774144—
Reactanttert-butyl{1-[2-(6,8-difluoro-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamateHCID 90849285—
Solvent1,4-DioxaneHCID 31275—
Product1-[2-(4-Aminopiperidin-1-yl)ethyl]-6,8-difluoroquinoxalin-2(1H)-oneHCID 66773980—

Reaction Steps

tert-Butyl{1-[2-(6,8-difluoro-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 194) was deprotected with HCl in dioxane as described for Intermediate 192.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08124602B2
Source datasetuspto-grants-2012_02
ORD IDord-487f841c1e8d4556ad4f10c21e39dcdd
Source noteuspto-grants-2012_02