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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1644494Generated: October 31, 2026

Trifluoroacetic acid → 1-(2-(4-aminopiperidin-1-yl)ethyl)-7-cyanoquinoxalin-2(1H)-one

https://huagongshe.com/reaction/1644494

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTrifluoroacetic acidHCID 6422—
Reactant1-[2-(4-Aminopiperidin-1-yl)ethyl]-2-oxo-1,2-dihydroquinoxaline-6-carbonitrileHCID 66774135—
Reactanttert-butyl{1-[2-(7-cyano-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamateHCID 68193061—
Product1-(2-(4-aminopiperidin-1-yl)ethyl)-7-cyanoquinoxalin-2(1H)-oneHCID 66774992—

Reaction Steps

tert-Butyl{1-[2-(7-cyano-2-oxoquinoxalin-1(2H)-yl)ethyl]piperidin-4-yl}carbamate (Intermediate 199) was deprotected with TFA as described for Intermediate 197 to give the crude free base of the product.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08124602B2
Source datasetuspto-grants-2012_02
ORD IDord-7795c82550624bf48e963392d68ffe46
Source noteuspto-grants-2012_02