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HRID1644506

反应详情

EQUATION

反应方程式

HRID 1644506 的结构方程式

REACTANTS

反应物

5
结构：O=Cc1cc2c(cn1)OCCO2
HCID21873668

2,3-Dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde

C8H7NO3

结构：CC(C)(C)OC(=O)N1C[C@@H](N)CC[C@@H]1CCN1C(=O)COc2ccc(C#N)cc21
HCID66774232

未命名化合物

结构：CC(C)(C)OC(=O)N1C[C@H](N)CC[C@H]1CCN1C(=O)COc2ccc(C#N)cc21
HCID66775001

未命名化合物

结构：CCOC(=O)[C@H]1CC[C@@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C
HCID69185078

未命名化合物

结构：CCOC(=O)[C@@H]1CC[C@H](O[Si](C)(C)C(C)(C)C)CN1C(=O)OC(C)(C)C
HCID86642662

未命名化合物

PRODUCTS

生成物

1
结构：N#Cc1ccc2c(c1)N(CC[C@@H]1CC[C@@H](NCc3cc4c(cn3)OCCO4)CN1)C(=O)CO2
HCID66774824

未命名化合物

PROCEDURE

实验过程

The product was obtained following the procedure described for Example 105, except, the enantiomer of Intermediate 183, tert-butyl(2S,5R)-5-amino-2-[2-(6-cyano-3-oxo-2,3-dihydro-4H-1,4-benzoxazin-4-yl)ethyl]piperidine-1-carboxylate (prepared by the exact route as Intermediate 183, but starting from 1-tert-butyl 2-ethyl(2S,5S)-5-{[tert-butyl(dimethyl)silyl]oxy}piperidine-1,2-dicarboxylate, the enantiomer of Intermediate 191) was reacted with 2,3-dihydro[1,4]dioxino[2,3-c]pyridine-7-carbaldehyde to yield the named compound.

WORKUP

后处理

  1. customThe product was obtained
  2. customto yield the named compound