Ammonia → HCID 24769741, compound

Participants

Reaction Steps

was obtained in analogy to the method indicated in Example 1 g) from 1-amino-6-chloro-4-(2-nitrophenyl)-3,4-dihydroisoquinoline hydrochloride by hydrogenation with PtO2 and MPLC and an elution mixture of 10 parts by volume of ethyl acetate, 5 parts by volume of n-heptane, 5 parts by volume of dichloromethane, 5 parts by volume of methanol and 1 part by volume of concentrated aqueous ammonia solution. The product was dissolved in a little ethyl acetate, acidified with ethereal HCl, stirred at room temperature and filtered off with suction.

Provenance & Evidence