反应详情

A solution of 6-amino-5-nitronicotinic acid (10 g) and concentrated sulfuric acid (20 ml) in ethanol (250 ml) was heated under reflux for 18 hr. The reaction mixture was concentrated, diluted with water and adjusted with sodium hydrogencarbonate to pH 8. The precipitated crystals were collected by filtration and washed with water to give the title compound (8.5 g, yield 73%) as yellow crystals. purity 84%. M+H: 212.

1. temperatureunder reflux for 18 hr
2. concentrationThe reaction mixture was concentrated
3. additiondiluted with water
4. filtrationThe precipitated crystals were collected by filtration
5. washwashed with water