反应详情

To a solution of {2-[5-(benzyloxy)-2-isopropoxyphenyl]-3H-imidazo[4,5-b]pyridin-6-yl}methanol (1.0 g) in dichloromethane (50 ml) was added manganese peroxide (2.3 g), and the mixture was stirred at room temperature for 8 hr. The insoluble material was removed by filtration, and the filtrate was concentrated. The obtained crude crystals were washed with diethyl ether to give the title compound (0.70 g, yield 69%) as colorless crystals. melting point 170-171° C. purity 87%. M+H: 388. 1H NMR (CDCl3) δ: 1.52 (6H, d, J=6.0 Hz), 4.76-4.85 (1H, m), 5.17 (2H, s), 7.03-7.07 (1H, m), 7.11-7.16 (1H, m), 7.31-7.52 (5H, m), 8.20 (1H, d, J=3.2 Hz), 8.53 (1H, s), 8.88 (1H, d, J=1.5 Hz), 10.19 (1H, s).

1. customThe insoluble material was removed by filtration
2. concentrationthe filtrate was concentrated
3. customThe obtained crude crystals
4. washwere washed with diethyl ether