Sodium Bicarbonate → HCID 178497319, compound

Participants

Reaction Steps

A solution of 2-[5-(benzyloxy)-2-isopropoxyphenyl]-3H-imidazo[4,5-b]pyridine-5-carbonitrile (60 mg) in hydrochloric acid-methanol (5 ml) was heated under reflux for 6 hr. The reaction mixture was adjusted with aqueous sodium hydrogencarbonate solution to pH 8, and extracted with ethyl acetate. The extract was washed with water; dried over magnesium sulfate and concentrated. The obtained crude crystals were washed with ethanol to give the title compound (40 mg, yield 61%) as colorless crystals. purity 95%. M+H: 418. 1H NMR (CDCl3) δ: 1.50 (6H, d, J=6.2 Hz), 4.06 (3H, s), 4.75-4.82 (1H, m), 5.17 (2H, s), 7.02-7.07 (1H, m), 7.10-7.15 (1H, m), 7.31-7.50 (5H, m), 8.12-8.22 (3H, m), 11.17 (1H, s).

Provenance & Evidence