HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Chloro-6-(4-fluorophenyl)pyrimidin-2-amine → N4-[3,5-Difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-(4-fluorophenyl)-pyrimidine-2,4-diamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Chloro-6-(4-fluorophenyl)pyrimidin-2-amine | HCID 11218353 | — |
| Reactant | 3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)aniline | HCID 17979287 | — |
| Product | N4-[3,5-Difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]-6-(4-fluorophenyl)-pyrimidine-2,4-diamine | HCID 58733331 | — |
Reaction Steps
Analogously to example 25, the title compound is synthesized from 100 mg (0.36 mmol) of [3,5-difluoro-4-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)phenyl]amine (from example XXXIV) and 110 mg (0.36 mmol) of 4-chloro-6-(4-fluorophenyl)pyrimidine-2-amine (from example LIX). Purification by preparative HPLC gives the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737153B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-264cf6ce27744ec28c5418ff6d73779a |
| Source note | uspto-grants-2010_06 |