5-Bromopyridine-2,3-diamine → HCID 59243060, compound

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Reaction Steps

The final product (217) was obtained using the procedure described for Example 191 except that 3-(2-fluorobenzyloxy)-5-((3-methylpyridin-2-yl)methoxy)benzaldehyde (217c) and 2,3-diamino-5-bromopyridine were used. 1H NMR (400 MHz, 90% DMSO-d6; 10% CDCl3) δ ppm 8.46 (br s, 1H), 8.39 (s, 1H), 8.11 (s, 1H), 7.78 (m, 1H), 7.52 (s, 1H), 7.48 (m, 1H), 7.45 (m, 2H), 7.40 (m, 2H), 7.16 (t, 1H, J=8.2 Hz), 7.08 (t, 1H, J=8.2 Hz), 6.79 (s, 1H), 5.32 (s, 2H), 5.19 (s, 2H), 2.31 (s, 3H). Calc'd for C26H20BrFN4O2; m/z (M+2H+)=521; found 521.

Provenance & Evidence