Potassium Carbonate → HCID 59243107, compound

Participants

Reaction Steps

Methyl 3-(2-fluorobenzyloxy)-5-hydroxybenzoate (1.9 g, 1.0 eq., 6.9 mmole) was reacted with tert-butyl bromoacetate (1.6 g, 1.2 eq., 8.3 mmole) in the presence of potassium carbonate (2.4 g., 2.5 eq., 17.3 mmole) in dimethylformamide (5 mL) over 18 h. The product was partitioned between ethyl acetate and aqueous media. The combined organic extracts were dried over magnesium sulfate, filtered and evaporated to give 2.4 g (89% yield) of a yellow oil. The LC/MS was as expected with an (M+H+) of 391 calculated and found.

Provenance & Evidence