HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-(4-(trifluoromethyl)benzyl)-1H-pyrazol-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 4-Nitro-1-{[4-(trifluoromethyl)phenyl]methyl}-1H-pyrazole | HCID 66776171 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Product | 1-(4-(trifluoromethyl)benzyl)-1H-pyrazol-4-amine | HCID 57551198 | 99.5% |
Reaction Steps
4-Nitro-1-(4-trifluoromethyl-benzyl)-1H-pyrazole (2.40 g, 0.00867 mol) was dissolved in Methanol (3.0E1 mL, 0.74 mol) and 10% Palladium on carbon (0.180 g) was added. The reaction was hydrogenated under balloon pressure for 2 days. The reaction was filtered through celite and concentrated in vacuo to give 2.08 g of product as a red oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124610B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-deaa12f2adc74f719f535c4d462c31f1 |
| Source note | uspto-grants-2012_02 |