Cesium carbonate → HCID 66776329, compound

Participants

Reaction Conditions

Reaction Steps

A suspension of 5-nitroindazole (1.098 g, 0.006731 mol), 1-bromo-4-phenylbutane (1.52 g, 0.00713 mol) and cesium carbonate (2.70 g, 0.00829 mol) in N,N-dimethylformamide (15 mL) was degassed with Ar for 10 min and then heated at 120° C. in a microwave for 50 min. The reaction was poured into water and extracted with methylene chloride (3×). The combined organics were washed with water and brine and then dried over MgSO4, filtered, and concentrated. The residue was purified by flash column chromatography to give the two regioisomers 5-nitro-1-(4-phenylbutyl)-1H-indazole and 5-nitro-2-(4-phenylbutyl)-2H-indazole as an inseparable mixture.

Provenance & Evidence