HCID 25204028, compound → HCID 57551223, compound

HRID 1644672Notes

Reaction equation

HRID 1644672 reaction equation
C(C1S[C:8]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([NH:20][C:21]3[S:22][CH:23]=[CH:24][N:25]=3)(=[O:19])=[O:18])=[CH:13][CH:12]=2)=NC=1C)(C)(C)C.C(C1SC(N[C:37]2[CH:42]=[CH:41][C:40](S(NC3SC=CN=3)(=O)=O)=[C:39](F)[CH:38]=2)=NC=1C)(C)(C)C.C(N1C(NC2C=CC(S(NC3SC=CN=3)(=O)=O)=C(F)C=2)=[CH:61][C:60]([CH2:80]C2C=CC(Cl)=CC=2)=N1)(C)(C)C.O=[C:89]1CC2C(=CC=C(S(NC3SC=CN=3)(=O)=O)C=2)[N:90]1C1SC=C(CC2C=CC(C(F)(F)F)=CC=2)N=1.C1(C2C=CN=C(NC3C=CC(S(NC4SC=CN=4)(=O)=O)=C(F)C=3)N=2)CC1.ClC1C=CC(CC2C=C(NC3C=NC(S(NC4SC=CN=4)(=O)=O)=NC=3)N(C)N=2)=CC=1.C(C1N=C(NC2CC3C(=CC=C(S(NC4SC=CN=4)(=O)=O)C=3F)C2)SC=1)(C)(C)C.FC1C(S(NC2SC=CN=2)(=O)=O)=CC=C2C=1C(=O)C(NC1SC=C(CC(C)(C)C)N=1)C2.FC1C=CC(CC2C=C(N3CCC4C(=CC(S(NC5SC=CN=5)(=O)=O)=CC=4)C3)ON=2)=CC=1.FC1C=CC(CC2C=C(N3CC(=O)C4C(=CC(S(NC5SC=CN=5)(=O)=O)=CC=4)C3)ON=2)=CC=1.C1(C2N=C(N(C3C=CC(S(=O)(=O)NC4SC=CN=4)=CC=3)CC(N)=O)SC=2)CC1>>[C:37]1([CH2:61][CH2:60][CH2:80][CH2:8][N:10]2[C:11]3[C:12](=[CH:13][C:14]([S:17]([NH:20][C:21]4[S:22][CH:23]=[CH:24][N:25]=4)(=[O:18])=[O:19])=[CH:15][CH:16]=3)[CH:89]=[N:90]2)[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

Participants

12

Reactant 11

HCID 25204028HCID 25204028, compoundHCID 25204033HCID 25204033, compoundHCID 86626361HCID 86626361, compoundHCID 86626362HCID 86626362, compoundHCID 86626363HCID 86626363, compoundHCID 86626364HCID 86626364, compoundHCID 86626365HCID 86626365, compoundHCID 86626366HCID 86626366, compoundHCID 86626367HCID 86626367, compoundHCID 86626368HCID 86626368, compoundHCID 86626369HCID 86626369, compound

Product 1

HCID 57551223HCID 57551223, compound

Procedure

Additional compounds of the invention, which have been synthesized according to the methods described herein are set forth below and listed in Table IV: 4-(5-tert-butyl-4-methylthiazol-2-ylamino)-N-(thiazol-2-yl)benzenesulfonamide; 4-(5-tert-butyl-4-methylthiazol-2-ylamino)-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide; 4-(1-tert-butyl-3-(4-chlorobenzyl)-1H-pyrazol-5-ylamino)-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide; 2-oxo-N-(thiazol-2-yl)-1-(4-(4-(trifluoromethyl)benzyl)thiazol-2-yl)indoline-5-sulfonamide; 4-(4-cyclopropylpyrimidin-2-ylamino)-2-fluoro-N-(thiazol-2-yl)benzenesulfonamide; 5-(3-(4-chlorobenzyl)-1-methyl-1H-pyrazol-5-ylamino)-N-(thiazol-2-yl)pyrimidine-2-sulfonamide; 2-(4-tert-butylthiazol-2-ylamino)-4-fluoro-N-(thiazol-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide; 4-fluoro-2-(4-neopentylthiazol-2-ylamino)-3-oxo-N-(thiazol-2-yl)-2,3-dihydro-1H-indene-5-sulfonamide; 2-(3-(4-fluorobenzyl)isoxazol-5-yl)-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide; 2-(3-(4-fluorobenzyl)isoxazol-5-yl)-4-oxo-N-(thiazol-2-yl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide; 2-((4-cyclopropylthiazol-2-yl)(4-(N-thiazol-2-ylsulfamoyl)phenyl)amino)acetamide.

Workup

  1. customAdditional compounds of the invention, which have been synthesized

Sources & evidence

ORD record
ord-66b884e90673455eba03d5dd3c0692a1
Source dataset
uspto-grants-2012_02
Patent number
US08124610B2

Reaction notes

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