HCID 59350816, compound → HCID 46202304, compound

HRID 1644754Notes

Reaction equation

HRID 1644754 reaction equation
C[O:2][C:3](=[O:29])[CH2:4][C:5]1[CH:14]=[C:13]([CH:15]([C:18]2[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=2)[O:16][CH3:17])[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([F:28])[CH:11]=2)[CH:6]=1>C(O)(=O)C>[F:28][C:10]1[CH:11]=[C:12]2[C:7](=[CH:8][CH:9]=1)[CH:6]=[C:5]([CH2:4][C:3]([OH:29])=[O:2])[CH:14]=[C:13]2[CH:15]([C:18]1[CH:23]=[CH:22][C:21]([S:24]([CH3:27])(=[O:26])=[O:25])=[CH:20][CH:19]=1)[O:16][CH3:17]

Participants

3

Reactant 1

HCID 59350816HCID 59350816, compound

Product 1

HCID 46202304HCID 46202304, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Starting with {6-fluoro-4-[(4-methanesulfonyl-phenyl)-methoxy-methyl]-naphthalen-2-yl}-acetic acid methyl ester, and using the method analogous to the one described for example 2-1, final step, 6-fluoro-4-[(4-methanesulfonyl-phenyl)-methoxy-methyl]-naphthalen-2-yl}-acetic acid (36 mg, 99%) was obtained as a white solid. 1H NMR (300 MHz, CDCl3) δ ppm: 7.78-7.93 (m, 3 H), 7.75 (br. s, 1 H), 7.50-7.68 (m, 4 H), 7.16-7.31 (m, 1 H), 5.80 (s, 1 H), 3.84 (s, 2 H), 3.45 (s, 3 H), 3.02 (s, 3 H); HRMS (ESI+) cald. for C21H19FO5S [(M+Na)+] 425.0829, obsd. 425.0827.

Sources & evidence

ORD record
ord-4f31904073e84da7aa191e2dd238138d
Source dataset
uspto-grants-2012_02
Patent number
US08124629B2

Reaction notes

Loading…