HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-(Methylthio)thiazol-2-amine | HCID 351678 | — |
| Reactant | p-Acetoxybenzoyl chloride | HCID 2756254 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate | HCID 57571820 | 84.1% |
Reaction Steps
Following the procedure for the synthesis of example 82, intermediate 510 (0.815 g, 4.10 mmol) dissolved in dry THF (25.0 mL), triethylamine (0.572 mL, 4.10 mmol), and 512 (0.500 g, 3.42 mmol) dissolved in dry THF (10.0 mL) gave 76 (0.887 g, 84%) as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124632B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8d44449e1a8c41379451b80e62cd026b |
| Source note | uspto-grants-2012_02 |