HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-(Methylthio)thiazol-2-amine | HCID 351678 | — |
| Reactant | 3-(Chlorocarbonyl)phenyl acetate | HCID 12998558 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-{[5-(Methylsulfanyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate | HCID 57571876 | 65% |
Reaction Steps
Following the procedure for the synthesis of example 85, intermediate 511 (0.815 g, 4.10 mmol) dissolved in dry THF (25.0 mL), triethylamine (0.572 mL, 4.10 mmol), and 512 (0.500 g, 3.42 mmol) dissolved in dry THF (10.0 mL) gave 77 (0.681 g, 65%) as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124632B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-87b1021b2334444d9a687967c9394846 |
| Source note | uspto-grants-2012_02 |