Sodium Hydroxide → HCID 25028925, compound

Participants

Reaction Steps

To a solution of benzoate of Step D (4.0 g, 5.93 mmol) in 200 mL of methanol was added 6.0 mL of 2 M sodium hydroxide. The reaction mixture was maintained at ambient temperature for 1 hr, and diluted with 1200 mL ether. The organic layer was washed with 1 M sodium hydroxide (400 mL). The organic layer was then washed with water, dried over MgSO4, filtered, and concentrated to afford a white solid. The crude material was purified by flash chromatography (0-5% then 5-7% them 7% methanol in ethyl acetate. M++1: 571.2.

Provenance & Evidence