[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]amine → N4-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-6-pyridin-4-ylpyrimidine-2,4-diamine

Participants

Role	Name	HCID	Charge
Reactant	[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]amine	HCID 17979279	—
Reactant	4-Chloro-6-(pyridin-4-yl)pyrimidin-2-amine	HCID 22324286	—
Product	N4-[4-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluorophenyl]-6-pyridin-4-ylpyrimidine-2,4-diamine	HCID 58733265	—

Reaction Steps

Analogously to example 25, the title compound is prepared from 19.7 mg (0.08 mmol) of [4-(2,3-dihydro-1H-pyrrolo[2,3-b]pyridin-4-yloxy)-3-fluoro-phenyl]amine (from example XLVI) and 17.4 mg (0.08 mmol) of 4-chloro-6-(4-pyridinyl)-2-pyrimidineamine (from example XXIX). Purification by preparative HPLC gives the product.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07737153B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-7b3fbd2cfec44d04bd0b462477bec2f5
Source note	uspto-grants-2010_06