Boron Trichloride → HCID 66775157, compound

HRID 1644849Notes

Reaction equation

HRID 1644849 reaction equation
[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:17]=[C:16]([CH2:18][CH:19]([CH3:21])[CH3:20])[S:15][C:14]=3[S:22]([NH:25]C(C)(C)C)(=[O:24])=[O:23])=[CH:9][CH:8]=2)[CH:5]=[N:4][CH:3]=[N:2]1.B(Cl)(Cl)Cl>ClCCl>[N:1]1([CH2:6][C:7]2[CH:12]=[CH:11][C:10]([C:13]3[CH:17]=[C:16]([CH2:18][CH:19]([CH3:21])[CH3:20])[S:15][C:14]=3[S:22]([NH2:25])(=[O:23])=[O:24])=[CH:9][CH:8]=2)[CH:5]=[N:4][CH:3]=[N:2]1

Participants

4

Reactant 2

HCID 25135Boron TrichlorideHCID 66775751HCID 66775751, compound

Product 1

HCID 66775157HCID 66775157, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3-(4-[1,2,4]Triazol-1-ylmethylphenyl)-5-iso-butyl-N-tert-butylthiophene-2-sulfonamide (146.4 mg, 0.34 mmol, see step (b) above) was mixed with BCl3 (1M solution in hexane) (2 mL, 1.7 mmol) in 5 mL of dichloromethane at rt and stirred for 1 h. The reaction mixture was extracted with ethyl acetate and water and subsequently dried over K2CO3. The solvent was evaporated and the resultant product was sufficiently pure to be used directly in the next step.

Workup

  1. extractionThe reaction mixture was extracted with ethyl acetate and water
  2. dry with materialsubsequently dried over K2CO3
  3. customThe solvent was evaporated

Sources & evidence

ORD record
ord-f31cf58b177e47bdb55d5c7e4730ec97
Source dataset
uspto-grants-2012_02
Patent number
US08124638B2

Reaction notes

Loading…