Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl 2-amino-6-chloropyrimidine-4-carboxylate → Methyl 2-amino-6-{[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amino}pyrimidine-4-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl 2-amino-6-chloropyrimidine-4-carboxylate | HCID 239687 | — |
| 반응물 | 5-(4-Amino-2-fluorophenoxy)-1H-indazole | HCID 17979271 | — |
| 생성물 | Methyl 2-amino-6-{[3-fluoro-4-(1H-indazol-5-yloxy)phenyl]amino}pyrimidine-4-carboxylate | HCID 17979335 | — |
반응 단계
Analogously to example 53, the title compound is synthesized from 1.01 g (4.05 mmol) of 5-(4-amino-2-fluorophenoxy)-1H-indazole (from example XII) and 0.84 g (4.06 mmol) of methyl 2-amino-6-chloropyrimidine-4-carboxylate.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07737153B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-5903844fe660446a9703d8144d4ce3b0 |
| 출처 메모 | uspto-grants-2010_06 |