HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Amino-2-methylphenol → 4-(5-amino-2-methylphenoxy)-N-methylpyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Amino-2-methylphenol | HCID 17818 | — |
| Reactant | 4-Chloro-N-methylpicolinamide | HCID 1476814 | — |
| Product | 4-(5-amino-2-methylphenoxy)-N-methylpyridine-2-carboxamide | HCID 23614556 | — |
Reaction Steps
Entry 50: According to Method A2, Step 4, 5-amino-2-methylphenol was reacted with 4-chloro-N-methyl-2-pyridinecarboxamide, which had been synthesized according to Method A2, Step 3b, to give 3-(2-(N-methylcarbamoyl)-4-pyridyloxy)-4-methylaniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 3-(2-(N-methylcarbamoyl)-4-pyridyloxy)-4-methylaniline to afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124630B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-f2c2f67088b241d096a800fa98a3d59b |
| Source note | uspto-grants-2012_02 |