HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Aminophenol → 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Aminophenol | HCID 403 | — |
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | 4-chloro-N,N-dimethylpyridine-2-carboxamide | HCID 4962252 | — |
| Reactant | 4-chloropyridine-2-carbonyl Chloride | HCID 11095146 | — |
| Product | 4-(4-aminophenoxy)-N,N-dimethylpyridine-2-carboxamide | HCID 23614563 | — |
Reaction Steps
Entry 59: 4-Chloropyridine-2-carbonyl chloride was reacted with dimethylamine according to Method A2, Step 3b. The resulting 4-chloro-N,N-dimethyl-2-pyridinecarboxamide was reacted with 4-aminophenol according to Method A2, Step 4 to give 4-(2-(N,N-dimethylcarbamoyl)-4-pyridyloxy)aniline. According to Method C1a, 4-chloro-3-(trifluoromethyl)phenyl isocyanate was reacted with 4-(2-(N,N-dimethylcarbamoyl)-4-pyridyloxy)aniline to afford the urea.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124630B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-28825d4745924e43864183ab1892d06e |
| Source note | uspto-grants-2012_02 |