HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → {(R)-4-[(3-methanesulfonyl-5-trifluoromethyl-benzene-sulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | [(R)-4-(3-methanesulfonyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester | HCID 59152955 | — |
| Product | {(R)-4-[(3-methanesulfonyl-5-trifluoromethyl-benzene-sulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester | HCID 59152898 | — |
Reaction Steps
Starting with [(R)-4-(3-methanesulfonyl-5-trifluoromethyl-benzenesulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester (example 5-1) and methyl iodide using the method analogous to the one described for example 2-1, {(R)-4-[(3-methanesulfonyl-5-trifluoromethyl-benzene-sulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester was obtained MS cald. for C20H24F3N3O6S2 523, obsd. (ESI+) [(M+H)+]: 524.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124641B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8c0a6fdd6fa54f5294257d7166182239 |
| Source note | uspto-grants-2012_02 |