Methyl iodide → HCID 59152928, compound

HRID 1645157Notes

Reaction equation

HRID 1645157 reaction equation
[CH2:1]([O:3][C:4](=[O:30])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([NH:15][S:16]([C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([F:29])[CH:20]=3)(=[O:18])=[O:17])[C:9]=2[CH:8]=[N:7]1)[CH3:2].[CH3:31]I>>[CH2:1]([O:3][C:4](=[O:30])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([N:15]([S:16]([C:19]3[CH:24]=[C:23]([C:25]([F:28])([F:27])[F:26])[CH:22]=[C:21]([F:29])[CH:20]=3)(=[O:18])=[O:17])[CH3:31])[C:9]=2[CH:8]=[N:7]1)[CH3:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 59153052HCID 59153052, compound

Product 1

HCID 59152928HCID 59152928, compound

Procedure

Starting with [(R)-4-(3-fluoro-5-trifluoromethyl-benzene-sulfonylamino)-4,5,6,7-tetrahydro-indazol-1-yl]-acetic acid ethyl ester (prepared by a method described above for example 1-1) and methyl iodide, using the method analogous to the one described for example 2-1, {(R)-4-[(3-fluoro-5-trifluoro-methyl-benzenesulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester (500 mg, 94%) was prepared as a white solid. LC-MS cald. for C19H21F4N3O4S 463, obsd. (ESI+) [(M+H)+] 464.

Workup

  1. customprepared by a method
  2. customwas prepared as a white solid

Sources & evidence

ORD record
ord-5a7b92d602a249eeaeefddcc58ef8dee
Source dataset
uspto-grants-2012_02
Patent number
US08124641B2

Reaction notes

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